Abstract
The condensation of 2-pyrazolin-5-ones with phenyl isothiocyanate, followed by reaction of the resulting thiolate ions with chloroacetyl chloride, phenacyl bromide, oxalyl chloride, 1,4-dibromo-2,3-butanedione and ethyl chloroformate, resulted in cyclisation to S,N-heterocycles in all cases. 2-Iminothiazolidin-4-ones, with phenyl isothiocyanate and then chloroacetyl chloride or phenacyl bromide, similarly formed 2,4′-bi(thiazolidine)-derived products.
Keywords
Chloroacetyl chloride
Phenacyl bromide
Chemistry
Phenyl isothiocyanate
Bromide
Pyrazolones
Oxalyl chloride
Ethyl chloroformate
Chloride
Medicinal chemistry
Thiazolidine
Phenylhydrazine
Isothiocyanate
Chloroformate
Hydrazide
Organic chemistry
Subject Areas
Synthesis and biological activity
·Organic Chemistry ·Physical Sciences
Synthesis of heterocyclic compounds
·Organic Chemistry ·Physical Sciences
Synthesis and Reactivity of Sulfur-Containing Compounds
·Organic Chemistry ·Physical Sciences
Citations by Year
2012: 1
2013: 2
2017: 3
2019: 1
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