Abstract
The first biosensor was described in 1962 by Clark and Lyons who immobilized glucose oxidase (GOD) on an amperometric oxygen electrode surface semipermeable dialysis membrane in order quantify glucose concentration in a sample directly [1, 2]. They described how to make electrochemical sensors (pH, polarographic, potentiometric or conductometric) more intelligent by adding enzyme transducers as membrane enclosed sandwiches.
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